The aim is to construct a picture of what models of psychedelic-assisted psychotherapy are currently adopted in clinical research and to report on their clinical outcomes. Ad-hoc and adapted therapeutic methods were identified. Common principles, points of divergence and future directions are highlighted and discussed with special attention toward therapeutic stance, degree of directiveness and the potential suggestive effects of information provided to patients.

The present work aims at summarising the state of knowledge and at highlighting relevant areas that are instrumental to the understanding and advancement of research in the field. After an introduction aimed at explaining what psychedelics are and how they work, we will discuss their suggested mechanism of action, the importance of the blinding problem in modern age RCTs.

Exploring these principles, procedures, underlying hypotheses and tenets could open a new line of research that has the potential to provide support to the idea that psychedelics are not just therapeutic agents per se but rather enabling factors of Psychedelic Psychotherapy: a tool exploiting increased contextual sensitivity to achieve and consolidate psychological health, relational satisfaction, deeper self‐awareness, and existential fulfillment. Finally, this research could reinforce arguments aimed at shifting public perception of such agents, a crucial component of the cultural feedback loop that may impact long‐term clinical outcomes in patients.